Endoplasmic Reticulum Stress and Unfolded Protein Response leaf node


URI

https://openalex.org/T11150

Label

Endoplasmic Reticulum Stress and Unfolded Protein Response

Description

This cluster of papers focuses on the molecular mechanisms, regulation, and consequences of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). It explores the role of ER stress in various diseases such as diabetes, cancer, neurodegenerative diseases, and liver disease, highlighting its impact on cell fate decisions, protein folding, oxidative stress, and apoptosis. The cluster also delves into the involvement of UPR pathways, chaperones, and the interplay between ER stress and inflammation.

Implementation

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@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://openalex.org/T11150> a skos:Concept ;
    rdfs:label "Endoplasmic Reticulum Stress and Unfolded Protein Response"@en ;
    rdfs:isDefinedBy openalex: ;
    owl:sameAs <https://en.wikipedia.org/wiki/Endoplasmic_reticulum_stress>,
        <https://openalex.org/T11150> ;
    skos:broader oasubfields:1307 ;
    skos:definition "This cluster of papers focuses on the molecular mechanisms, regulation, and consequences of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). It explores the role of ER stress in various diseases such as diabetes, cancer, neurodegenerative diseases, and liver disease, highlighting its impact on cell fate decisions, protein folding, oxidative stress, and apoptosis. The cluster also delves into the involvement of UPR pathways, chaperones, and the interplay between ER stress and inflammation."@en ;
    skos:inScheme openalex: ;
    skos:prefLabel "Endoplasmic Reticulum Stress and Unfolded Protein Response"@en ;
    openalex:cited_by_count 1353314 ;
    openalex:works_count 34589 .